Pflugers Archiv European Journal of Physiology , 4 , Fong P, Gray MA. Orchestration of vectorial chloride transport by epithelia. In: Pusch, M, ed.
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The physiology of anion transport: Tales of the bizarre and unexpected. Experimental Physiology , 91 1 , In: 37th European Pancreatic Club Meeting. Effect of herpesvirus infection on pancreatic duct cell secretion. World Journal of Gastroenterology , 11 38 , Protein kinase C mediates the inhibitory effect of substance P on HCO 3- secretion from guinea pig pancreatic ducts.
A novel basolateral bicarbonate transport mechanism in human pancreatic duct cells. In: 36th European Pancreatic Club Meeting. Bicarbonate secretion: It takes two to tango. Nature Cell Biology , 6 4 , Pancreas , 28 4 , Murine epithelial cells: Isolation and culture. Journal of Cystic Fibrosis , 3 2 , Novel regulation of cystic fibrosis transmembrane conductance regulator CFTR channel gating by external chloride. Journal of Biological Chemistry , 40 , Recombinant sendai virus mediates CFTR gene transfer to airway epithelium both in vitro and in vivo.
The patch-clamp and planar lipid bilayer techniques: Powerful and versatile tools to investigate the CFTR Cl- channel. Journal of Cystic Fibrosis , 3 Suppl. Who's talking to whom? Epithelial-bacterial pathogen interactions.
Characterization of vectorial chloride transport pathways in the human pancreatic duct adenocarcinoma cell line HPAF. Substance P inhibits bicarbonate secretion from guinea pig pancreatic ducts by modulating an anion exchanger. Substance P inhibits bicarbonate secretion in guinea pig panceatic ducts by modulating an anion exchanger.
Gastroenterology , 4 , AA Designer pharmacotherapy for the treatment of cystic fibrosis. British Journal of Pharmacology , 4 , Designer pharmacotherapy for the treatment of cystic fibrosis: Commentary on Zegarra-Moran et al. Properties and role of calcium-activated chloride channels in pancreatic duct cells.
Current Topics in Membranes , 53 , In: Fuller, C. Synergistic antinociception between ZC88, an N-type voltage-dependent calcium channel blocker, and ibuprofen in mouse models of visceral and somatic inflammatory pain. Etiology and Pharmacology of Neuropathic Pain.
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References Publications referenced by this paper. Gabapentin for chronic neuropathic pain and fibromyalgia in adults.
R Andrew Moore , Phillip J. Structure of a complex between a voltage-gated calcium channel beta-subunit and an alphasubunit domain. Nature — Molecular properties of calcium channels. Hartmut H. Different aspirin regimens within the low-dose range, in small studies, have been able to restore a normal aspirin pharmacological responsiveness. Whether this variability can affect the clinical efficacy and safety of aspirin in cardiovascular prevention, especially in some primary prevention settings T2DM , and the risk-benefit profile of alternative ways of giving aspirin are the next challenges in the aspirin scenario.
The authors are indebted to Professor Carlo Patrono for invaluable advices and challenging discussions. National Center for Biotechnology Information , U. Journal List Thrombosis v. Published online Jan Author information Article notes Copyright and License information Disclaimer. Received Jun 20; Accepted Oct 4. Rocca and G. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. This article has been cited by other articles in PMC.
Abstract The main pharmacological aspects of pharmacodynamics PD and pharmacokinetics PK of aspirin as antiplatelet agent were unravelled between the late sixties and the eighties, and low-dose aspirin given once daily has been shown to be a mainstay in the current treatment and prevention of cardiovascular disorders. Open in a separate window. Figure 1. From Aspirin Resistance to Variability in Responsiveness Practicing physicians have long recognized that individual patients show wide variability in response to the same drug or treatment.
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Figure 2. Table 1 Main pharmacological features of drug resistance versus variability in drug response. Resistance Variability i is usually triggered by drug exposure , slowly reversible, and often drug specific i not induced by and often independent of the drug, can affect different drugs, and does not revert upon withdrawal ii implies a change of the drug target making it inaccessible or no longer inhibitable ii the drug target is not necessarily modified or inaccessible iii detectable by specific laboratory tests, which impact on the clinical decision of changing drug iii laboratory tests are of little help in therapeutic decisions if mechanism s are unknown c hange drug, increase dose, more frequent intake?
Figure 3. Table 3 Age-related plasma esterase activities. Figure 4. Figure 5. Acknowledgment The authors are indebted to Professor Carlo Patrono for invaluable advices and challenging discussions. References 1. Inhibitors of arachidonic acid metabolism, with especial reference to the aspirin-like drugs.
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In: Powles TJ, et al. Prostaglandins and Related Lipids. Liss; Vane JR. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. The effect of salicylates on the hemostatic properties of platelets in man. The Journal of Clinical Investigation. Effect of salicylates on human platelets. The Lancet. Acetylation of prostaglandin synthase by aspirin.
Aspirin selectively inhibits prostaglandin production in human platelets. Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides. Inhibition of platelet prostaglandin synthetase by oral aspirin. The mechanism of the effect of aspirin on human platelets.
Acetylation of a particulate fraction protein. Comparative evaluation of the inhibitory effects of aspirin-like drugs on prostaglandin production by human platelets and synovial tissue. Advances in Prostaglandin and Thromboxane Research. The structural basis of aspirin activity inferred from the crystal structure of inactivated prostaglandin H2 synthase.
Nature Structural Biology.
Clinical pharmacology of platelet cyclooxygenase inhibition. Low dose aspirin and inhibition of thromboxane B 2 production in healthy subjects. Thrombosis Research. Endogenous biosynthesis of prostacyclin and thromboxane and platelet function during chronic administration of aspirin in man. Dose-related kinetics of aspirin. Presystemic acetylation of platelet cyclooxygenase.
The New England Journal of Medicine. Prostaglandin endoperoxides. A new concept concerning the mode of action and release of prostaglandins. Rapid return of cyclo-oxygenase active platelets in dogs after a single oral dose of aspirin. Worthington RE, Nakeff A. Aspirin inhibits rat megakaryocyte thromboxane synthesis. Randomized trial of intravenous streptokinase, oral aspirin, both, or neither among 17, cases of suspected acute myocardial infarction: ISIS Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients.
British Medical Journal. Endogenous prostacyclin biosynthesis and platelet function during selective inhibition of thromboxane synthase in man. Bruton LL, editor.